Effectiveness of high-dose chemotherapy and transplantation of autologous hemopoietic cells in lymphogranulomatosis

Aim. To determine clinical effectiveness of high-dose polychemotherapy (PCT ) and transplantation of autologous hemopoietic cells (TAHC) in patients wi th lymphogranulomatosis (LGM). Material and methods. 27 LGM patients aged 16-42 years who have undergone T AHC after high-dose PCT (BEAM - 17 patients or CBV - 10 patients). 4 patien ts given high-dose PCT were in the first-second complete remission (CR), 7 patients - in the first partial remission (PR). Prior to TAHC, 8 patients h ad one, two and more relapses of LGM, and 8 patients had no remission at al l. Bone marrow, hemopoietic blood cells and both were transplanted to 17, 2 and 8 patients, respectively. Mobilization of hemopoietic blood cells and stimulation of hemopoiesis after TAHC were achieved using colony-stimulatin g factors. Results. The treatment resulted in CR or PR (from 6 to 95 months) in 70.4% of patients. The remission duration varied depending on the disease phase a t transplantation. Four patients who underwent TAHC in PR maintained it for 13-95 months (median 47.5 months). Lasting remission (29-59 months) were a chieved in 42.9 and 37.5% of patients who underwent TAHC in the first PR or in recurrent LGM. None of the patients was in remission longer than 2 year s after TAHC if high-dose PCT was conducted in advanced tumor process due t o resistant LGM or inadequate previous treatment. Infectious complications lethality early after the transplantation reach 7.4%(2 patients). Conclusion. High-dose PCT followed by TAHC is effective in LGM if the tumor is chemosensitive.