Erythropoietin drugs in patients with chronic renal failure at the stage of conservative treatment. Effectiveness and side effects

Aim. To assess activity and safety of erythropoietin (EP) drugs in conserva tive chronic renal failure (CRF). Material and methods, The antianemic effect of EP drugs, central and cardia c hemodynamics were studied in 28 CRF patients (mean blood creatinine 5.27 mg%) with renal anemia. In addition, arterial pressure was automatically me asured within 24 hours and the CRF progression rate,rns assessed Results, Low-dose EP drugs injected subcutaneously rapidly produced antiane mic and cardioprotective effects and may improve residual renal function. Conclusion, Pathogenetically grounded and safe for patients with conservati ve CRF is a combination of low-dose subcutaneous EP drugs with hypotensive drugs (calcium antagonists, ACE inhibitors), loop diuretics and low-protein diet.