Penicillazine, a unique quinolone derivative with 4H-5,6-dihydro-1,2-oxazine ring system from the marine fungus Penicillium sp (strain #386) from theSouth China Sea

Penicillazine (1) is a new compound with both quinolone and 4H-5,6-dihydro- 1,2-oxazine ring systems that was isolated from a culture of the marine fun gus Penicillum sp. (strain #386). Its structure was elucidated using spectr oscopic methods, primarily 2D NMR techniques, and was confirmed by an X-ray diffraction analysis. Variations in the H-1 NMR spectrum of penicillazine (1) were observed over a 65 degreesC tempcraturc range. (C) 2000 Elsevier S cience Ltd. All rights reserved.