Improved asymmetric syntheses of (R)-(-)-homocitrate and (2R,3S)-(-)-homoisocitrate, intermediates in the alpha-aminoadipate pathway of fungi

Authors
Ma, GX Palmer, DRJ
Citation
Gx. Ma et Drj. Palmer, Improved asymmetric syntheses of (R)-(-)-homocitrate and (2R,3S)-(-)-homoisocitrate, intermediates in the alpha-aminoadipate pathway of fungi, TETRAHEDR L, 41(48), 2000, pp. 9209-9212
Citations number
15
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
48
Year of publication
2000
Pages
9209 - 9212
Database
ISI
SICI code
0040-4039(20001125)41:48<9209:IASO(A>2.0.ZU;2-9
Abstract
Improved asymmetric syntheses of the title compounds are reported. Both pro ducts are produced through diastereoselective alkylation of malic acid; (R) -homocitrate synthesis uses the self-regeneration of stereocenters approach . Both procedures represent an improvement in yield over existing methods w ithout loss of stereoselectivity. (C) 2000 Elsevier Science Ltd. All rights reserved.