Stereoselective synthesis of optically active pyridyl alcohols via asymmetric transfer hydrogenation of pyridyl ketones

Authors
Okano, K Murata, K Ikariya, T
Citation
K. Okano et al., Stereoselective synthesis of optically active pyridyl alcohols via asymmetric transfer hydrogenation of pyridyl ketones, TETRAHEDR L, 41(48), 2000, pp. 9277-9280
Citations number
32
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
48
Year of publication
2000
Pages
9277 - 9280
Database
ISI
SICI code
0040-4039(20001125)41:48<9277:SSOOAP>2.0.ZU;2-M
Abstract
A chiral Ru(II) complex, RuCl[(S,S)-N-(p-toluenesulfonyl)-1,2-diphenyl-ethy lenediamine](p-cymene), serves as an efficient catalyst for asymmetric tran sfer hydrogenation of 2-acetylpyridine with a substrate to catalyst molar r atio of 200-1000 with HCOOH as a hydrogen source to give (S)-1-(2-pyridyl)e thanol in an almost quantitative yield and with 95% ee. (C) 2000 Elsevier S cience Ltd. All rights reserved.