Triplex-forming enhancement with high sequence selectivity by single 2 '-O,4 '-C-methylene bridged nucleic acid (2 ',4 '-BNA) modification

Authors
Obika, S Hari, Y Sugimoto, T Sekiguchi, M Imanishi, T
Citation
S. Obika et al., Triplex-forming enhancement with high sequence selectivity by single 2 '-O,4 '-C-methylene bridged nucleic acid (2 ',4 '-BNA) modification, TETRAHEDR L, 41(46), 2000, pp. 8923-8927
Citations number
27
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
46
Year of publication
2000
Pages
8923 - 8927
Database
ISI
SICI code
0040-4039(20001111)41:46<8923:TEWHSS>2.0.ZU;2-9
Abstract
Tripler-forming ability of the oligonucleotides containing one 2'-O,3'-C-me thyleneribonucleic acid (2',4'-BNA) unit was investigated by measurement of the melting temperature (T-m), and the 2',4'-BNA modification promoted the marked tripler stabilization in a highly sequence-selective manner. (C) 20 00 Elsevier Science Ltd. All rights reserved.