Amide catalysts with tetradentate ligands and the asymmetric transfer hydrogenation of carbonyl compounds

Authors
Marson, CM Schwarz, I
Citation
Cm. Marson et I. Schwarz, Amide catalysts with tetradentate ligands and the asymmetric transfer hydrogenation of carbonyl compounds, TETRAHEDR L, 41(46), 2000, pp. 8999-9003
Citations number
33
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
46
Year of publication
2000
Pages
8999 - 9003
Database
ISI
SICI code
0040-4039(20001111)41:46<8999:ACWTLA>2.0.ZU;2-W
Abstract
Amidic tetradentate catalysts comprising two trans-1,2-cyclohexanediamine u nits linked via a dicarbonyl spacer are shown to provide useful enantiomeri c excesses in the asymmetric transfer hydrogenation from propan-2-ol to aro matic ketones. N-Benzylation of the terminal amino groups results, in sever al cases, in reversal of the absolute configuration of the major product. ( C) 2000 Elsevier Science Ltd. All rights reserved.