Ak. Nersessian, CLASTOGENIC ACTION OF THIOTEPA ON BONE-MARROW CELLS OF THE ARMENIAN HAMSTER, Mutation research. Genetic toxicology testing, 322(4), 1994, pp. 287-290
Thiotepa (TT) induced chromosomal aberrations in the bone marrow cells
of the Armenian hamster, Cricetulus migratorius, in a dose-dependent
manner. The maximal clastogenic action was observed 24 h after treatme
nt with thiotepa. Male and female Armenian hamsters were similarly sen
sitive to the clastogenic action of thiotepa. The lowest effective con
centration of thiotepa for Armenian hamsters was 2.5 mg/kg b.w. (6.1%
of the LD(50)). The results obtained and analysis of the literature da
ta have shown that Armenian hamsters are much more resistant to the cl
astogenic action of thiotepa than various other species of rodent. Thi
s resistance is not due to the metabolic activation rates of chemical
mutagen in the liver of Armenian hamsters, since thiotepa is a direct-
acting clastogen.