Genotoxicity analysis and hazardousness prioritization of a group of chemicals

Genotoxic chemicals are increasingly being used in our daily life. 180-chem icals were screened to identify the priority of hazardousness from the poin t of view of their genotoxicity. Umu-test was used to evaluate the genotoxi city of these chemicals. Some chemicals exhibited high genotoxic response. A scoring algorithm was developed to evaluate the hazardousness level of th ese chemicals based on their genotoxicity level and four other characterist ics: biodegradation probability, soil adsorption coefficient (KOC), bioconc entration factor (BCF), Henry's Law constant (HLC). Then, these chemicals w ere sorted in a descending order of their hazardousness probability.