Simple and versatile synthesis of 2-alkoxyalkylamines

Facile synthesis of 2-methoxyalkylnitriles and 2-ethoxyalkylnitriles and th eir reduction to amines for potential usage as isocyanide synthesis startin g compounds is presented. Alkoxyalkylnitriles (methoxy and ethoxy) were pre pared by reaction of corresponding dialkyl ketals and trimethylsilyl cyanid e. This reaction was optimized for the highest yield and its usability was confirmed on series of dialkyl ketals. Following standard hydride reduction of appropriate methoxy or ethoxy nitriles gave corresponding methoxy or et hoxyamines. Identity and purity of all newly prepared compounds was confirm ed by means of NMR spectroscopy.