CHEMICAL STRUCTURES OF AMPHIDINOL-5 AND AMPHIDINOL-6 ISOLATED FROM MARINE DINOFLAGELLATE AMPHIDINIUM-KLEBSII AND THEIR CHOLESTEROL-DEPENDENT MEMBRANE DISRUPTION

Authors
PAUL GK MATSUMORI N KONOKI K MURATA M TACHIBANA K
Citation
Gk. Paul et al., CHEMICAL STRUCTURES OF AMPHIDINOL-5 AND AMPHIDINOL-6 ISOLATED FROM MARINE DINOFLAGELLATE AMPHIDINIUM-KLEBSII AND THEIR CHOLESTEROL-DEPENDENT MEMBRANE DISRUPTION, Journal of marine biotechnology, 5(2-3), 1997, pp. 124-128
Citations number
9
Categorie Soggetti
Biothechnology & Applied Migrobiology
Journal title
Journal of marine biotechnology → ACNP
ISSN journal
09412905
Volume
5
Issue
2-3
Year of publication
1997
Pages
124 - 128
Database
ISI
SICI code
0941-2905(1997)5:2-3<124:CSOAAA>2.0.ZU;2-6
Abstract
A series of polyhydroxy-polyene compounds were isolated from the cultu red dinoflagellate Amphidinium klebsii as well as from its surrounding media. Amphidinol 5 (AM 5) and 6 (AM 6) were found to be potent antif ungal and hemolytic agents. Their permeabilizing activity towards phos pholipid liposomes was markedly enhanced by the presence of cholestero l within the bilayer, indicating that the mechanism of action involved interaction with membranal cholesterol.