Epilepsia partialis continua in Creutzfeldt-Jakob disease

Objectives - We describe a patient with Creutzfeldt-Jakob disease (CJD) wit h epilepsia partialis continua (EPC) and complex partial seizures. Material , methods and results - The patient presented with semi-rhythmic jerking mo vements of the right upper extremity. serial EEG findings showed progressiv e changes with initial periodic lateralizing epileptiform discharges (PLEDs ) on the left hemisphere which evolved into more generalized periodic sharp wave complexes (PSWCs) at later stage. Video-LEG monitoring recorded compl ex partial seizures originating from the left hemisphere in addition to EPC . Conclusions - A diagnosis of CJD should be considered when a rapidly prog ressive dementia is accompanied by abnormal movements. EPC, although rare, may present as an initial manifestation of CJD.