Stiff-person like syndrome in a patient with multiple pituitary hormone deficiencies

A patient with long-standing, occult pituitary insufficiency, who developed painful muscle stiffness and superimposed spasms, closely resembling stiff -person syndrome, was described. Complete resolution of neuromuscular sympt oms with hormone replacement in this case, as well as in a previously repor ted one, led to the suggestion that a syndrome like stiff-person could repr esent a rare consequence of multiple pituitary hormone deficiencies.