3-Methylpyrazolin-5-ones (1a,b) were reacted with cyclo-alkanones (2a d) in
the presence of fused sodium acetate to give the corresponding cycloalkyli
dene derivatives (3a-h). Reaction of compounds 3a-h with malononitrile gave
the pyrano derivatives (4a-h), which were cyclized to pyranopyrimidines wi
th acetic anhydride/pyridine, formamide and formamide/formic acid. All the
synthesized spiroheterocycles derivatives were identified by conventional m
ethods (IR,H-1 NMR) and elemental analyses.