Synthesis of some new spiropyrazolo[4 ',5 ': 5,6]-pyrano[2, 3-d]pyrimidines

Authors
Citation
Ms. Al-thebeiti, Synthesis of some new spiropyrazolo[4 ',5 ': 5,6]-pyrano[2, 3-d]pyrimidines, AFINIDAD, 57(489), 2000, pp. 365-370
Citations number
30
Categorie Soggetti
Chemistry
Journal title
AFINIDAD
ISSN journal
00019704 → ACNP
Volume
57
Issue
489
Year of publication
2000
Pages
365 - 370
Database
ISI
SICI code
0001-9704(200009/10)57:489<365:SOSNS'>2.0.ZU;2-W
Abstract
3-Methylpyrazolin-5-ones (1a,b) were reacted with cyclo-alkanones (2a d) in the presence of fused sodium acetate to give the corresponding cycloalkyli dene derivatives (3a-h). Reaction of compounds 3a-h with malononitrile gave the pyrano derivatives (4a-h), which were cyclized to pyranopyrimidines wi th acetic anhydride/pyridine, formamide and formamide/formic acid. All the synthesized spiroheterocycles derivatives were identified by conventional m ethods (IR,H-1 NMR) and elemental analyses.