Effect of plant sterols from rice bran oil and triterpene alcohols from sheanut oil on serum lipoprotein concentrations in humans

Background: Intake of unsaponifiable compounds from edible oils, such as pl ant sterols, can lower serum cholesterol concentrations in humans. However, little is known about effects of other chemically related unsaponifiables in edible oils, such as triterpene alcohols. Objective: We studied the effects of plant sterols from rice bran oil and t riterpene alcohols from sheanut oil on cholesterol concentrations in health y, normolipemic volunteers. Design: Twenty-eight men and 32 women consumed 29 g/d of 3 margarines for 3 wk each on a crossover, double-blind basis. A margarine based on sunflower oil was used as the control. Concentrates of plant sterols from rice bran oil or triterpene alcohols from sheanut oil were added to make 2 experiment al margarines with the same fatty acid composition as the control margarine . Results: intake of 2.1 g plant sterols/d from rice bran oil decreased total cholesterol by 0.19 mmol/L (95% CI: -0.31, -0.07 mmol/L) and LDL cholester ol by 0.20 mmol/L (95% CI: -0.30, -0.10 mmol/L). HDL-cholesterol and triacy lglycerol concentrations did not change significantly. Intake of 2.6 g trit erpene alcohols/d from sheanut oil did not significantly affect lipoprotein concentrations in all subjects combined. Conclusions: We found that 2.1 g plant sterols/d from rice bran oil lowered serum total cholesterol by 5% and LDL cholesterol by 9% in normolipemic hu mans, whereas triterpene alcohols from sheanut oil did not significantly af fect lipoprotein concentrations in all subjects combined. The effect of ric e bran oil sterols is probably due to beta -sitosterol and other 4-desmethy lsterols and not to 4,4'-dimethylsterols.