Cervical spine anomalies and tumors in Weaver syndrome

Weaver syndrome is an autosomal dominant disorder comprising accelerated gr owth rate and rapidly advancing skeletal maturation. Previous reports sugge st that the phenotype in adults may be sufficiently subtle to make diagnosi s difficult. Half brothers with classical childhood findings of Weaver synd rome and their father with minimal clinical findings showed cervical spine anomalies that likely represent a consistent radiographic finding in this d isorder. One of the children represents the third occurrence of neoplasia i n Weaver syndrome. (C) 2000 Wiley-Liss, Inc.