Does immunosuppressive regimen influence the lipid disturbances in kidney recipients?

Though it is said that some immunosuppressive agents are implicated in the development of hyperlipidemia in kidney recipients, this subject is still c ontroversial. Main plasma lipid parameters, as well as apolipoproteins Al a nd B were measured periodically in 39 kidney first cadaveric, nondiabetic r ecipients during 24 months of clinic follow-up after transplantation. Stand ard triple immunosuppressive therapy: prednisone + cyclosporine + azathiopr ine was administrated from the beginning. After the second year of kidney t ransplantation, a significant reduction refers to values of TC, LDL, apo Al and apo B. In the group with antirejection - methylprednisolone therapy, a nd without it only TG in the 24th month and apo B in the ist month were sta tistically lower in the latter group (both p < 0.05). In the multiple regre ssion test, a linear coincidence was observed between apo Al, apo B and pre dnisone cumulative dosage after the Ist month, TG and cyclosporine in the 6 th month and LDL and cyclosporine in the 12th month after transplantation. It appears that steroids had an impact on lipids directly after transplanta tion, while cyclosporine did so thereafter. Copyright (C) 2000 S. Karger AG . Basel.