Impact of head-to-abdominal circumference asymmetry on outcomes in growth-discordant twins

OBJECTIVE: Our aim was to evaluate head-to-abdominal circumference asymmetr y as a marker for adverse outcomes in growth-discordant twins. STUDY DESIGN: We conducted a retrospective cohort study of asymmetric and s ymmetric twins with greater than or equal to 25% growth discordance, compar ing their outcomes with those in concordant symmetric twins. Growth was ter med asymmetric on the basis of a head circumference/abdominal circumference ratio at greater than or equal to 95th percentile on ultrasonography perfo rmed less than or equal to4 weeks before delivery. RESULTS: We evaluated 572 twin pairs. Asymmetric discordant twins were more likely than symmetric concordant twins to be delivered at less than or equ al to 34 weeks' gestation (57% vs 27%), to require intubation (36% vs 7%), to remain in intensive care >1 week (36% vs 3%), and to have an outcome com posite that included respiratory morbidity, intraventricular hemorrhage, se psis, or neonatal death (29% vs 6%), all P < .05. Symmetric discordant and symmetric concordant twins had similar outcomes. CONCLUSIONS: Discordant twins with head-to-abdominal circumference asymmetr y have an increased risk of morbidity. Moreover, in the absence of asymmetr y, outcomes are comparable among discordant and concordant twins.