Cessation of cerebral hemorrhage recurrence associated with corticosteroidtreatment in a patient with cerebral amyloid angiopathy

We report the case of a 65 year old female patient with biopsy-proven cereb ral amyloid angiopathy (CAA). She experienced intracerebral hemorrhages 4 t imes during 23 days but thee serous strokes did not recur after corticoster oid therapy was started and her condition greatly improved. Since high tite rs of antinuclear antibodies and elevated erythrocyte sedimentation rate we re found in her serum, she may have an inflammatory disorder involving amyl oid-laden cerebral vessels. This is the first report showing the usefulness of corticosteroid for the treatment of CAA-related cerebral hemorrhages. A dditionally, the concentrations of A beta 40 and A beta 42 in the CSF of th is patient decreased rapidly after the use of corticosteroid, and ultimatel y fell far below normal values.