End-of-life care of patients in the intensive care unit (ICU) often require
s dramatic shifts in attitudes and interventions, from traditional intensiv
e rescue care to intensive palliative care. The care of patients dying in I
CUs raises both clinical and ethical difficulties, Because fewer ICU patien
ts are able to make decisions about withdrawing treatment, careful attentio
n must be paid to previously expressed preferences and surrogate input Cult
ural and spiritual values of patients and families may differ markedly from
those of clinicians. Although prognostic models are increasingly able to p
redict mortality rates for groups of ICU patients, their usefulness in guid
ing specific decisions to forgo treatment has not been established. When a
decision to forgo treatment is made, the focus should be on specifying the
patient's goals of care and assessing all treatments in light of these goal
s; interventions that do not contribute to the patient's goals should be di
scontinued. Symptoms accompanying withdrawal of life support can almost alw
ays be controlled with appropriate palliative measures. After ICU intervent
ions are forgone, patient comfort must be the paramount objective. Whether
in the ICU or elsewhere, hospitals have an ethical obligation to provide se
ttings that offer dignified, compassionate, and skilled care.