Factors predicting prognosis of epilepsy after presentation with seizures

The objective of this study was to identify the factors, at the time of dia gnosis, that determine the prognosis for remission of epilepsy. A prospecti ve community-based cohort study of 792 patients recruited at the time of th eir first diagnosis of epileptic seizures was undertaken; in those classifi ed 6 months after presentation, the median follow-up period was 7.2 years ( quartiles at 6.2 and 8.2 years) after presentation. We analyzed data from 6 months after the first identified seizure, which prompted the dianosis of epilepsy, to allow us to factor in those aspects contingent on a diagnostic assessment. Baseline clinical and demographic data were analyzed using the Cox proportional hazards regression model with remission of epilepsy for 1 , 2, 3, and 5 years as outcome measures. The dominant clinical feature pred icting remission was the number of seizures in the 6-month diagnostic asses sment period Thus, the chance of entering 1 year of remission by 6 years fo r a patient who had 2 seizures during this initial 6 months was 95%; for 5 years of remission, it was 47% as opposed to 75% for 1 year of remission an d 24% for 5 years of remission if there had been 10 or more seizures during this period, The number of seizures in the early phase of epilepsy there, taken as the first 6 months after presentation) is the single most importan t predictive factor for both early and long-term remission of seizures.