Newer substituted beta-aminonaphthalenes as potent anti-inflammatory agents

Authors
Bansal, E Srivastava, VK Kumar, A
Citation
E. Bansal et al., Newer substituted beta-aminonaphthalenes as potent anti-inflammatory agents, ARZNEI-FOR, 50(11), 2000, pp. 1009-1014
Citations number
15
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH
ISSN journal
00044172 → ACNP
Volume
50
Issue
11
Year of publication
2000
Pages
1009 - 1014
Database
ISI
SICI code
0004-4172(200011)50:11<1009:NSBAPA>2.0.ZU;2-Y
Abstract
beta-[2-(3'-Chloro-2'-oxo-4'-substituted aryl-1'-azetidinyl)-thiazol-4-yl] aminonaphthalenes 13-17 and beta-[2-(1',3'-disubstitutedphenyl-formazan-4'- yl) aminonaphthalenes 8-12 were synthesized from beta-(2-arylideneamino-thi azol-4-yl)aminonaphthalenes 3-7 by diazotisation and by cycloaddition with monochloroacetyl chloride, respectively, on the azomethine group of the com pounds 3-7. The newly synthesized compounds showed potent anti-inflammatory and analgesic activities and were less ulcerogenic than phenylbutazone.