Triazine-based condensing reagents

The synthesis, properties, and application of condensing reagents derived f rom 1,3,5-triazines are described. The mechanism of activation of carboxyli c function, structure of reactive intermediates, and mechanism of acylation of nucleophiles are presented. The synthetic versatility of mono- and bifu nctional reagents for syntheses in solution, triazine-based immobilized rea gents, chiral triazines for enantiodifferentiating syntheses, are discussed . The scope and limitation of the synthetic utility of triazine reagents in the preparation of heterocyclic compounds, amides, esters, oligopeptides-i ncluding large-scale syntheses and use in the combinatorial chemistry-is de monstrated (C) 2000 John Wiley & Sons, Inc.