We examined whether starvation affected the amount of EF-2 protein as well
as the level of its mRNA in the liver and skeletal muscle of mice, to under
stand the molecular mechanism for nutritional adaptation of protein-turnove
r. Although the amount of EF-2 was diminished by starvation in each of the
tissues examined, the amount of EF-2 mRNA did not decrease in parallel with
the protein.