Increase of macrophage migration inhibitory factor in sera of patients with iridocyclitis

Aims-To determine whether macrophage migration inhibitory factor (MIF) leve ls were increased in sera of the patients with iridocyclitis. Methods-Sera were obtained from 41 patients with acute iridocyclitis, 13 pa tients with chronic iridocyclitis, and 44 healthy control subjects. A MIF l evels were determined by a human MIF ELISA. Results-The average levels of MIF in the sera of patients with both acute a nd chronic iridocyclitis were significantly higher than that of healthy sub jects. Conclusion-Uveitis induces the elevation of serum MIF, which may affect var ious inflammatory symptoms in uveitis.