I. Celik et al., Efficacy of polyvinylpolypyrrolidone in reducing the immunotoxicity of aflatoxin in growing broilers, BR POULT SC, 41(4), 2000, pp. 430-439
1. Protective action of an enzyme-linked polyvinylpolypyrrolidone (PVPP, My
cofix(R) Plus) against the immunosuppressive effect of afatoxins (AF) was e
valuated by determination of peripheral blood TP-lymphocyte proportions and
splenic plasma cell counts. Histological changes in lymphoid organs were a
lso investigated by light microscopy. One-d-old broiler chicks (Hybro) rece
ived 2.5 mg/kg diet AF (83.06% AFB(1), 12.98% AFB(2), 2.84% AFG(1), 1.12% A
FG(2)) with or without PVPP (3 g/kg diet) until 21 d of age.
2. When compared with the controls, AF treatment significantly decreased pe
ripheral T-lymphocyte counts. AF caused a slight decrease in splenic plasma
cell counts. The addition of PVPP to an AF-containing diet significantly i
ncreased T-lymphocyte counts. Splenic plasma cell counts were numerically i
ntermediate between control and AF groups.
3. The dietary addition of PVPP to AF-free diet did not significantly alter
either T-lymphocyte or splenic plasma cell counts.