Efficacy of polyvinylpolypyrrolidone in reducing the immunotoxicity of aflatoxin in growing broilers

Citation
I. Celik et al., Efficacy of polyvinylpolypyrrolidone in reducing the immunotoxicity of aflatoxin in growing broilers, BR POULT SC, 41(4), 2000, pp. 430-439
Citations number
62
Categorie Soggetti
Animal Sciences
Journal title
BRITISH POULTRY SCIENCE
ISSN journal
00071668 → ACNP
Volume
41
Issue
4
Year of publication
2000
Pages
430 - 439
Database
ISI
SICI code
0007-1668(200009)41:4<430:EOPIRT>2.0.ZU;2-4
Abstract
1. Protective action of an enzyme-linked polyvinylpolypyrrolidone (PVPP, My cofix(R) Plus) against the immunosuppressive effect of afatoxins (AF) was e valuated by determination of peripheral blood TP-lymphocyte proportions and splenic plasma cell counts. Histological changes in lymphoid organs were a lso investigated by light microscopy. One-d-old broiler chicks (Hybro) rece ived 2.5 mg/kg diet AF (83.06% AFB(1), 12.98% AFB(2), 2.84% AFG(1), 1.12% A FG(2)) with or without PVPP (3 g/kg diet) until 21 d of age. 2. When compared with the controls, AF treatment significantly decreased pe ripheral T-lymphocyte counts. AF caused a slight decrease in splenic plasma cell counts. The addition of PVPP to an AF-containing diet significantly i ncreased T-lymphocyte counts. Splenic plasma cell counts were numerically i ntermediate between control and AF groups. 3. The dietary addition of PVPP to AF-free diet did not significantly alter either T-lymphocyte or splenic plasma cell counts.