Clinical presentation, endoscopic features, and treatment of gastric metastases from breast carcinoma

BACKGROUND. Breast carcinoma is the most common malignancy in women. Metast atic involvement of the stomach is not well known. METHODS. Endoscopic features and treatment options were evaluated retrospec tively for 51 patients with gastric metastases of breast carcinoma. RESULTS. The presenting sites of metastases were skeleton (43%), stomach (2 7%), lung (8%), and liver (4%). Diagnosis of gastric involvement was histol ogically confirmed in 41 patients and based on endoscopic features, despite negative biopsies in 10 patients. Six patients (12%) presented with nonfat al hemorrhage; in the others, symptoms were nonspecific: anorexia (71%), ep igastric pain (53%), and vomiting (41%). Endoscopy showed 3 patterns: 18% l ocalized lesions, 57% diffuse infiltration, and 25% external compression at the cardia or pylorus. Histology showed mainly lobular breast carcinoma (n = 36) compared with ductal carcinoma (n = 10) and other types (n = 5), con trary to the usual distribution. The overall response to systemic therapy w as 46% (17 of 37 treated patients). Median survival from detection of gastr ic metastases was 10 months, with a 2-year survival rate of 23%. CONCLUSIONS. Gastric metastases usually derive from lobular rather than duc tal breast carcinoma. Endoscopy revealed mainly a diffuse linitis plastica- like infiltration. Chemotherapy or hormonal treatment may result in fair pa lliation in selected patients, although many patients are heavily pretreate d. Cancer 2000;89:2214-21. (C) 2000 American Cancer Society.