This paper describes a research programme undertaken for the solution of a
serious industrial powder handling problem; the achievement of steady, cont
rollable, reproducible discharge of a fine pharmaceutical powder from an in
termediate storage vessel to the main process reactor. The use of computer
simulations, specifically the discrete element method (DEM) was central to
the programme. DEM offers explanations of material phenomenology and sugges
ts possible practical solutions using information which may be difficult or
impossible to obtain in practice using traditional observation and experim
ental techniques. It is suggested that the programme is an example of a gen
eral strategy which may be useful when traditional heuristic, experience-ba
sed methods of powder how problem solving prove inadequate.