The purpose of this study was to determine the extent to which the Home Obs
ervation for Measurement of the Environment (HOME; Caldwell & Bradley, 1980
) Inventory provides useful information about the social environment of med
ically fragile infants. The HOME was scored, and maternal and infant intera
ctive behaviors were observed in the home at 6 and 12 months corrected age
for 60 medically fragile infants (28 who were neurologically normal and 32
who were neurologically compromised) and their mothers. The Bayley Scales o
f Infant Development-Ii (Bayley, 1993) Mental Development Index (MDI) was a
dministered at 16 months. The total HOME score showed high internal consist
ency, with moderate consistency for the subscales. The HOME correlated with
observed maternal and child behaviors, but the relations were stronger for
the neurologically normal infants. The HOME Inventory at 6 and 12 months w
as related to the Bayley MDI for both neurologically normal and compromised
infants. These results indicate that the HOME Inventory can provide useful
information for medically fragile infants, even those infants with neurolo
gical impairments.