Fibrodysplasia ossificans progressiva: Report of two cases

Fibrodysplasia Ossificans Progressiva (FOP) is a rare hereditary connective tissue disease, genetically inherited as an autosomal dominant tr ait with complete penetrance but variable expressivity. Onset is typically in child hood and progressive involvement of the spine and proximal extremities lead s to immobility and articular dysfunction. We present two cases with the ty pical features of FOP and a review of the pathogenesis, clinical manifestat ions and treatment options of this rare disease.