Polymyalgia rheumatica (PMR) is a generally benign syndrome involving the n
eck shoulder; and hip girdles in the elderly. However; none of the clinical
and laboratory findings are specific for this syndrome. Different diseases
may present with features suggesting PMR. The consideration of other condi
tions which in some cases resemble PMR is very important, as their therapy
and prognosis differ completely from that of PMR. Four patients presenting
with typical PMR manifestations, who were finally diagnosed as having condi
tions very different from PMR, are described The importance of the differen
tial diagnosis in patients presenting with polymyalgia symptoms is underlin
ed.