F. Mauvais-jarvis et al., A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes, DIABETES, 49(12), 2000, pp. 2126-2134
Type 2 diabetes is a polygenic disease characterized by defects in both ins
ulin secretion and insulin action. We have previously reported that isolate
d insulin resistance in muscle by a tissue-specific insulin receptor knocko
ut ((MIRKO mouse) is not sufficient to alter glucose homeostasis, whereas b
eta -cell-specific insulin receptor knockout (beta IRKO) mice manifest seve
re progressive glucose intolerance due to loss of glucose-stimulated acute-
phase insulin release. To explore the interaction between insulin resistanc
e in muscle and altered insulin secretion, me created a double tissue-speci
fic insulin receptor knockout in these tissues. Surprisingly, beta IRKO-MIR
KO mice show an improvement rather than a deterioration of glucose toleranc
e when compared to beta IRKO mice. This is due to improved glucose-stimulat
ed acute insulin release and redistribution of substrates with increased gl
ucose uptake in adipose tissue and liver in vivo, without a significant dec
rease in muscle glucose uptake. Thus, insulin resistance in muscle leads to
improved glucose-stimulated first-phase insulin secretion from beta -cells
and shunting of substrates to nonmuscle tissues, collectively leading to i
mproved glucose tolerance. These data suggest that muscle, either via chang
es in substrate availability or by acting as an endocrine tissue, communica
tes with and regulates insulin sensitivity in other tissues.