Synthesis and functionalization of new tropanes designed for use as scaffolds in combinatorial chemistry

Authors
Paparin, JL Crevisy, C Toupet, L Gree, R
Citation
Jl. Paparin et al., Synthesis and functionalization of new tropanes designed for use as scaffolds in combinatorial chemistry, EUR J ORG C, (23), 2000, pp. 3909-3918
Citations number
27
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
1434193X → ACNP
Issue
23
Year of publication
2000
Pages
3909 - 3918
Database
ISI
SICI code
1434-193X(200012):23<3909:SAFONT>2.0.ZU;2-C
Abstract
The [4+3] cycloaddition reaction between alkyloxycarbonyl-substituted pyrro les and alpha,alpha'-dibromo ketones in the presence of diethylzinc has bee n extended to a wide range of substrates. The functionalization of the resu lting tropanes has been studied. It is demonstrated that such tropanes repr esent potentially useful scaffolds.