Potential anticancer drugs, 4 - Glycosyl glycerol derivatives as drug carrier system. Stereoselective synthesis of epoxyalkyl N-acyl-beta-D-glucopyranosides and their reactivity with nucleophiles

The synthesis of alkenyl 2-acylamino-4,6-O-benzylidene-2-deoxy-beta -D-gluc opyranosides from N-acetyl-D-glucosamine is described. The oxidation of alk enyl glycosides with m-CPBA gives the corresponding oxiranes in good yields , and with high stereoselectivity. Analogues of glycosyl glycerol derivativ es, which can be used as drug carriers, were obtained by various ring-openi ng reactions with different nitrogen, sulfur, and carbon nucleophiles.