Matrix metalloproteinase inhibitors and cancer

Authors
Lauer-Fields, JL Fields, GB
Citation
Jl. Lauer-fields et Gb. Fields, Matrix metalloproteinase inhibitors and cancer, EXPERT OP T, 10(12), 2000, pp. 1873-1884
Citations number
48
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EXPERT OPINION ON THERAPEUTIC PATENTS
ISSN journal
13543776 → ACNP
Volume
10
Issue
12
Year of publication
2000
Pages
1873 - 1884
Database
ISI
SICI code
1354-3776(200012)10:12<1873:MMIAC>2.0.ZU;2-2
Abstract
The matrix metalloproteinase (MMP) family plays an integral role in both no rmal and pathological connective tissue remodeling. The accelerated local t urnover of the extracellular matrix is often found in tumour cell invasion and metastasis. The development of MMP inhibitors thus offers a promising s trategy to modulate metastasis. This review describes developments in MMP i nhibitor research and patents related to cancer since 1998.