Decline of life's energy theory of ageing - 2. Restoration of anabolic andregulatory processes

The precipitous decline of anabolic hormone levels that occurs as humans an d animals age results in a decline of cellular energy production throughout the whole body. It is this decline that allows the deterioration of the bo dy and leads us to pose the obvious questions: should we attempt to re-esta blish the hormonal synchrony and mid-life hormonal levels? And, if we resto re both the hormone regulation and the hormone levels will the body be revi talised to a stable mid-life metabolic status? The answers to these questio ns have significant social, economic and personal implications. The body an d mind fail progressively, after mid-life, in the absence of any hormonal r estoration. The failure is due to a decline in the energy producing capacit y of individual cells as an effect of declining stimulation by anabolic hor mones. The lower levels, particularly of dehydroepiandrosterone (DHEA) and growth hormone (GH), precede the dysfunctional changes that occur in bodily tissues. A wealth of literature and multiple patients have been published that reflect the practicality of DHEA, melatonin and growth hormone replace ment to constructively stimulate cellular energy production and the body's synthetic capabilities. Melatonin administration is reported to synchronise dampened and offset circadian cycles and to support the return of tissue a nd cellular homeostasis. Recombinant growth hormone and/or insulin-like gro wth factor-1 (IGF-1) administrations positively restore many metabolic proc esses but the effects of boluses of these hormones, while therapeutic, do n ot stimulate circadian pulsatile rhythms of hormone secretion. Physiologica l (diurnal and pulsatile) secretion of growth hormone has been shown to req uire the administration of patented synthetic growth hormone secretagogues (releasing factor mimics that are not yet widely clinically available). Or alternately, oral administration of Alcarnor(TM), a patented composition of acetyl carnitine and L-ornithine that stimulates growth hormone secretion patterns that are both diurnal and pulsatile. The restoration or maintenanc e of mid-life [33-38] anabolic hormone rhythms and levels promises to thwar t the physical and mental ailments and chronic diseases that are presently identified with old age.