The effect of aqueous feat extract on the spontaneous contractile activityof smooth muscles

The Effect of Aqueous Feat Extract on the Spontaneous Contractile Activity of Smooth Muscles Background: There are reports in the literature about the effects of peat a nd its products on spontaneous contractile activity (SCA) of smooth muscles . In our earlier work we showed that the aqueous peat extract is a stimulus for SCA of smooth muscle fibres. After longstanding (4-5 h) influence from aqueous peat extract, a self blocking effect of these influences can be ob served. The mechanism of action could not be determined up to now. Purpose: The purpose of this study is to elucidate the peat mechanism of ac tion. Material and Methods: In organ baths, the effects of aqueous pleat extract on the SCA from smooth muscles have been studied under normal conditions an d with presence of different receptor blocking substances. Results: Our investigations show that only with simultaneous blocking of al pha (2) and D-2 receptors the stimulating activity of aqueous peat extract on the SCA of smooth muscle fibres can be suppressed. The self blocking act ions of the stimulating activity of aqueous peat extract on the SCA of smoo th muscles are interconnected with blocking of alpha (2) adreno and D-2 rec eptors. Conclusion: The aqueous peat extract contains biologically active substance s, which have a partial agonistic effect on alpha (2) and D-2 dopamine rece ptors. Corresponding to the results we start out at pharmacological effects as they are known from the mentioned receptors. The clinical efficacy have to be shown by clinical trials.