SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF 2-(SUBSTITUTED PHENYL)-3-(2OR 3-[(4-SUBSTITUTED PHENYL-4-HYDROXY)PIPERIDINO]ETHYL OR PROPYL)-1,3-THIAZOLIDIN-4-ONES

Authors
DIURNO MV MAZZONI O CAPASSO F IZZO AA BOLOGNESE A
Citation
Mv. Diurno et al., SYNTHESIS AND PHARMACOLOGICAL ACTIVITY OF 2-(SUBSTITUTED PHENYL)-3-(2OR 3-[(4-SUBSTITUTED PHENYL-4-HYDROXY)PIPERIDINO]ETHYL OR PROPYL)-1,3-THIAZOLIDIN-4-ONES, Il Farmaco, 52(4), 1997, pp. 237-241
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
52
Issue
4
Year of publication
1997
Pages
237 - 241
Database
ISI
SICI code
0014-827X(1997)52:4<237:SAPAO2>2.0.ZU;2-S
Abstract
A series of aryl-hydroxy-piperidinoalkyl-thiazolidinones was synthesiz ed and evaluated to inhibit castor oil-induced diarrhea in mice. The d ose dependent antidiarrheal activity of the most active compound )4-hy droxy)piperidino]ethyl]-1,3-thiazolidin-4-one (6) was counteracted by naloxone, resulting comparable with that of loperamide, a mu opiate ag onist.