alpha-thalassaemia (Hb-Bart's) in Rajasthan (India)

Citation
Sl. Choubisa et al., alpha-thalassaemia (Hb-Bart's) in Rajasthan (India), HAEMATOLOGI, 30(3), 2000, pp. 209-213
Citations number
26
Categorie Soggetti
Hematology
Journal title
HAEMATOLOGIA
ISSN journal
00176559 → ACNP
Volume
30
Issue
3
Year of publication
2000
Pages
209 - 213
Database
ISI
SICI code
0017-6559(2000)30:3<209:A(IR(>2.0.ZU;2-P
Abstract
A total of 1647 cord blood samples (618 of scheduled tribes, 487 of schedul ed castes and 542 of general castes) of newborns from the Banswara, Bhilwar a, Chittorgarh, Dungarpur, Sirohi and Udaipur districts of the Aravali hill y region of Rajasthan were investigated electrophoretically for evidence of Hb-Bart's (alpha -thalassaemia). Hb-Bart's was encountered in 31 (1.88%) n eonates constituting 1.8 to 12.6% of their total haemoglobin. Of these, 24 (1.46%) were of alpha -thalassaemia 1 and 7 (0.42%) of alpha -thalassaemia 2. The incidence of alpha -thalassaemia genes varied from 3.07% in the sche duled tribes, 1.43% in the scheduled castes to 0.77% in the general castes populations giving an overall incidence of 1.88%. Except Hb-Bart's allele, no other mutant haemoglobins were observed.