Proinflammatory and antitumor properties of interleukin-18 in the gastrointestinal tract

Authors
Pages, F Berger, A Lebel-Binay, S Zinzindohoue, F Danel, C Piqueras, B Carriere, O Thiounn, N Cugnenc, PH Fridman, WH
Citation
F. Pages et al., Proinflammatory and antitumor properties of interleukin-18 in the gastrointestinal tract, IMMUNOL LET, 75(1), 2000, pp. 9-14
Citations number
44
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY LETTERS
ISSN journal
01652478 → ACNP
Volume
75
Issue
1
Year of publication
2000
Pages
9 - 14
Database
ISI
SICI code
0165-2478(200012)75:1<9:PAAPOI>2.0.ZU;2-Z
Abstract
Interleukin-18 (IL-18) plays a central role in the immune response by actin g on Tn1 cell differentiation, cell-mediated cytotoxicity and inflammation. The role of IL-1s in cancers and inflammatory diseases is discussed in the light of our investigations on IL-18 synthesis in normal colonic mucosa, c olonic cancer and Crohn's disease (CD). (C) 2000 Elsevier Science B.V. All rights reserved.