Cell-cycle regulation in immunity, tolerance and autoimmunity

To trigger nn effective immune response, lymphocytes must proliferate. In a ddition to their direct involvement in cell-cycle progression, cell-cycle r egulators might thus control immune functions. Recent evidence suggests tha t these regulators are essential for T-cell function; we argue that their s tudy will provide cities for dissecting anergy and tolerance mechanisms, as well as for intervention in autoimmune diseases.