Lymphocytes rearrange, edit and revise their antigen receptors to be useful yet safe

Authors
Fink, PJ McMahan, CJ
Citation
Pj. Fink et Cj. Mcmahan, Lymphocytes rearrange, edit and revise their antigen receptors to be useful yet safe, IMMUNOL TOD, 21(11), 2000, pp. 561-566
Citations number
45
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
21
Issue
11
Year of publication
2000
Pages
561 - 566
Database
ISI
SICI code
0167-5699(200011)21:11<561:LREART>2.0.ZU;2-A
Abstract
Pamela Fink and Catherine McMahan discuss how B and T cells test for useful antigen receptors and weed out potentially harmful ones, with special atte ntion paid to T-cell receptor revision, a newly described mechanism by whic h mature T cells can maintain self tolerance.