Lymphocytes with a complex: adapter proteins in antigen receptor signaling

Authors
Tomlinson, MG Lin, J Weiss, A
Citation
Mg. Tomlinson et al., Lymphocytes with a complex: adapter proteins in antigen receptor signaling, IMMUNOL TOD, 21(11), 2000, pp. 584-591
Citations number
62
Categorie Soggetti
Immunology
Journal title
IMMUNOLOGY TODAY
ISSN journal
01675699 → ACNP
Volume
21
Issue
11
Year of publication
2000
Pages
584 - 591
Database
ISI
SICI code
0167-5699(200011)21:11<584:LWACAP>2.0.ZU;2-D
Abstract
Adapters can be defined as proteins that mediate intermolecular interaction s within a signal transduction pathway and that lack both intrinsic enzymat ic and transcriptional activity. Their essential role in lymphocyte signali ng was revealed by recent analyses of mice and cell lines deficient in LAT, SLP-76 and BLNK. These and other adapters nucleate signaling complexes and facilitate coupling of antigen receptor triggering to functional responses in lymphocytes.