L-Arginine in coronary atherosclerosis

Nitric oxide is formed from the N-guanido terminal of the amino acid L-argi nine and from molecular oxygen by nitric oxide synthase enzymes. L-arginine administration improves the coronary blood flow response to acetylcholine in patients with normal coronary arteries and hypercholesterolemia, reverse s the defective endothelium-dependent vasodilation associated with an eleva ted plasma low-density lipoprotein level or hypercholesterolemia, dilates c oronary epicardial arteries and stenoses, enhances nitric oxide generation, and inhibits lesion formation after balloon angioplasty. Stimulation of en dogenous nitric oxide production could inhibit atherogenesis, and therefore may be of benefit in patients with risk factors for atherosclerosis. (C) 2 000 Elsevier Science Ireland Ltd. All rights reserved.