Changes in findings of mammography, ultrasonography and contrast-enhanced computed tomography of three histological complete responders with primary breast cancer before and after neoadjuvant chemotherapy: Case reports

We report the changes in the findings of imaging examinations (mammography, ultrasonography and contrast-enhanced computed tomography) of three patien ts with primary breast cancer before and after neoadjuvant chemotherapy, wh o obtained histologically complete responses after the chemotherapy. The ne oadjuvant chemotherapy consisted of four cycles of doxorubicin and docetaxe l. All patients were clinically judged as partial responders, because of th e remaining tumorous lesions in the imaging examinations. However, these tu morous lesions could be related to the chemotherapy-induced fibrosis and tu mor necrosis or the remaining fibrocystic changes. In this study, it was co nsidered very difficult to estimate the extent of residual tumors accuratel y in patients with primary breast cancer after neoadjuvant chemotherapy by any type of imaging examination.