Quinolactacins A, B and C: Novel quinolone compounds from Penicillium sp EPF-6 I. Taxonomy, production, isolation and biological properties

Quinolactacins A (1), B (2) and C (3), novel quinolone antibiotics have bee n found from the cultured broth of a fungal strain isolated from the larvae of the mulberry pyralid (Margaronia pyloalis Welker). The fungal strain, E PF-6 was identified as Penicillium sp, from its morphological characteristi cs. Quinolactacins were obtained from the culture medium by solvent extract ion and chromatographic purification. Compound 1 showed inhibitory activity against turner necrosis factor (TNF) production induced by murine peritone al macrophages and macrophage-like J774.1 cells stimulated with lipopolysac charide (LPS).