Synthesis and activity of analogues of SB-219383: Novel potent inhibitors of bacterial tyrosyl tRNA synthetase

Authors
Berge, JM Broom, NJP Houge-Frydrych, CSV Jarvest, RL Mensah, L McNair, DJ O'Hanlon, PJ Pope, AJ Rittenhouse, S
Citation
Jm. Berge et al., Synthesis and activity of analogues of SB-219383: Novel potent inhibitors of bacterial tyrosyl tRNA synthetase, J ANTIBIOT, 53(11), 2000, pp. 1282-1292
Citations number
10
Categorie Soggetti
Microbiology
Journal title
JOURNAL OF ANTIBIOTICS
ISSN journal
00218820 → ACNP
Volume
53
Issue
11
Year of publication
2000
Pages
1282 - 1292
Database
ISI
SICI code
0021-8820(200011)53:11<1282:SAAOAO>2.0.ZU;2-Z
Abstract
SB-219383 is a naturally occurring antibiotic, which acts by inhibition of tyrosyl tRNA synthetase. Semi-synthetic derivatives of SB-219383 were prepa red with the objective of elucidating the key features required for inhibit ion of tyrosyl tRNA synthetase in order to improve the antibacterial activi ty. Some ester and amide derivatives as well as monocyclic analogues exhibi ted sub-nanomolar inhibitory activity against tyrosyl tRNA synthetase.