Fa. Aly et al., Determination of phenolic sympathomimetic drugs in pharmaceutical samples and biological fluids by flow-injection chemiluminescence, J AOAC INT, 83(6), 2000, pp. 1299-1305
A rapid and highly sensitive flow-injection chemiluminometric method was de
veloped for determination of 3 sympathomimetic drugs, namely, etilefrine hy
drochloride, isoxsuprine hydrochloride, and prenalterol hydrochloride. The
method is based on chemiluminescence induced by oxidation of drugs with aci
dified potassium permanganate in the presence of formic acid as a carrier.
The calibration graphs were linear over the concentration ranges 0.2-9, 0.2
-12.5, and 0.025-1.25 mug/mL for the 3 compounds, respectively. The method
was applied successfully in determining the drugs in dosage forms and in bi
ological fluids. A proposal for the reaction pathway is suggested.