LeadScope: Software for exploring large sets of screening data

Modern approaches to drug discovery have dramatically increased the speed a nd quantity of compounds that are made and tested for potential potency. Th e task of collecting, organizing, and assimilating this information is a ma jor bottleneck in the discovery of new drugs. We have developed LeadScope a novel, interactive computer program for visualizing, browsing, and interpr eting chemical and biological screening data that can assist pharmaceutical . scientists in finding promising drug candidates. The software organizes t he chemical data by structural features familiar to medicinal chemists. Gra phs are used to summarize the data, and structural classes are highlighted that are statistically correlated with biological activity.