Hydrophylic surfactant-imidazole derivative association studied by RPLC using a hydroorganic solution

A high-performance liquid chromatographic (HPLC) method for an association study of imidazole derivatives in surfactant micellars using a hydrophilic detergent, i.e. Montanox DF 80 was presented. The thermodynamic results obt ained showed that imidazole association in the surfactant micelles was effe ctive over a concentration of surfactant equal to approximatively 4.10(-4) mol/l. In addition, an enthalpy-entropy compensation study revealed that th e type of interaction between the solute and the RP18 stationary phase was independent of the molecular structure. The thermodynamic variations observ ed were considered to be the result of equilibrium displacement between the solute and free ethanol (respectively free surfactant) and its clusters (r espectively to micelles) created in the mobile phase. (C) 2000 Elsevier Sci ence B.V. All rights reserved.